Article

Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops

2023-03-15

Abstract excerpt

Lineage-defining transcription factors form densely interconnected circuits in chromatin occupancy assays, but the functional significance of these networks remains underexplored. We reconstructed the functional topology of a leukemia cell transcription network from the direct gene-regulatory programs of eight core transcriptional regulators established in pre-steady state assays coupling targeted protein degradat...

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Literature Corpus work: ea9a654b-3bf2-5539-b4b1-f18829c23047
DOI: 10.1101/2023.03.13.532438

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