Article

Control of MYC-dependent apoptotic threshold by a co-amplified ubiquitin E3 ligase UBR5

2019-01-08

Abstract excerpt

MYC protein expression has to be tightly controlled to allow for maximal cell proliferation without inducing apoptosis. Here we discover UBR5 as a novel MYC ubiquitin ligase and demonstrate how it functions as a molecular rheostat to prevent excess accumulation of MYC protein. UBR5 effects on MYC protein stability are independent on N-terminal FBW7 degron of MYC. Endogenous UBR5 inhibition induces MYC protein expr...

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Literature Corpus work: 3e8a2912-0311-56a3-a206-a60e5acd55d8
DOI: 10.1101/515247

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