Article

Systematically characterizing the roles of E3-ligase family members in inflammatory responses with massively parallel Perturb-seq

2023-01-24

Abstract excerpt

<h4>ABSTRACT</h4> E3 ligases regulate key processes, but many of their roles remain unknown. Using Perturb-seq, we interrogated the function of 1,130 E3 ligases, partners and substrates in the inflammatory response in primary dendritic cells (DCs). Dozens impacted the balance of DC1, DC2, migratory DC and macrophage states and a gradient of DC maturation. Family members grouped into co-functional modules that wer...

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Literature Corpus work: c6b9a9db-1548-5bcd-92a2-3d6df195de61
DOI: 10.1101/2023.01.23.525198

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