Article

A novel AR molecular glue degrader via bivalent engagement of the N-terminal domain and RNF213–UBE2J2 complex

2026-07-16

Abstract excerpt

Targeted protein degradation enables the elimination of disease-relevant proteins through induced proximity between E3 ligases and substrates. Current androgen receptor (AR) therapies act via the ligand-binding domain (LBD) but fail against constitutively active LBD mutants or splice variants such as AR-V7. Here, we identify GZL626, a small-molecule degrader that induces proteasome-dependent degradation of both fu...

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Literature Corpus work: bf5f4f03-0b0c-5402-a7fb-f501ebc0a78e
DOI: 10.64898/2026.07.14.738453

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