Orphan quality control shapes network dynamics and gene expression

Abstract excerpt

All eukaryotes require intricate protein networks to translate developmental signals into accurate cell fate decisions. Mutations that disturb crucial interactions between network components often result in disease, but how the composition and dynamics of complex networks are established is unknown. Here, we identify the tumor suppressor E3 ligase UBR5 as a quality control enzyme that helps degrade unpaired subuni...

Topics

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• Apoptosis
• Gene Expression
• HEK293 Cells
• HeLa Cells
• Mutation
• Signal Transduction
• Transcription Factors
• Ubiquitin-Protein Ligases

Identifiers and source

Literature Corpus work

a6c23cfb-afd9-5657-8b07-b72ab8a15c50

DOI

10.1101/2022.11.06.515368