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Article

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes

20 Jul 2023

Abstract excerpt

Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, and Black individuals have a higher incidence of ischemic stroke than White individuals. However, it is not known whether the A allele is responsible for worse stroke...

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PMID: 37471144
DOI: 10.1172/jci169608

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