Article
The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition.
Journal of thrombosis and haemostasis : JTH - 1 Dec 2018
Whitley M J, Henke D M, Ghazi A, Nieman M, Stoller M, Simon L M, Chen E, Vesci J, Holinstat M, McKenzie S E, Shaw C A, Edelstein L C, Bray P F
Abstract excerpt
Essentials The rs773902 SNP results in differences in platelet protease-activated receptor (PAR4) function. The functional consequences of rs773902 were analyzed in human platelets and stroke patients. rs773902 affects thrombin-induced platelet function, PAR4 desensitization, stroke association. Enhanced PAR4 Thr120 effects on platelet function are blocked by ticagrelor. SUMMARY: Background F2RL3 encodes...
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