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Article

Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2018

Tourdot Benjamin E, Stoveken Hannah, Trumbo Derek, Yeung Jennifer, Kanthi Yogendra, Edelstein Leonard C, Bray Paul F, Tall Gregory G, Holinstat Michael

Abstract excerpt

OBJECTIVE: Platelet activation after stimulation of PAR (protease-activated receptor) 4 is heightened in platelets from blacks compared with those from whites. The difference in PAR4 signaling by race is partially explained by a single-nucleotide variant in PAR4 encoding for either an alanine or threonine at amino acid 120 in the second transmembrane domain. The current study sought to determine whether the...

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Identifiers

PMID: 29748334
DOI: 10.1161/ATVBAHA.118.311112
PMCID: PMC6023764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.PMID 29748334Read ↗

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