Article

A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet Reactivity

2023-12-01

Abstract excerpt

<h4>Background</h4> Protease activated receptor 4 (PAR4) mediates thrombin signaling on platelets and other cells. Our recent structural studies demonstrated a single nucleotide polymorphism in extracellular loop 3 (ECL3), PAR4-P310L (rs2227376) leads to a hypo-reactive receptor. <h4>Objectives</h4> The goal of this study was to determine how the hypo-reactive PAR4 variant in ECL3 impacts platelet function in vi...

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Literature Corpus work: 7b5a68a6-ab79-5df1-b7da-a06d269bc079
DOI: 10.1101/2023.12.01.569075

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