Article

Human PAR1 expressed on mouse platelets contributes to hemostasis and arterial occlusion

2025-06-07

Abstract excerpt

<h4>Summary</h4> Thrombin (FIIa) signaling through protease-activated receptors (PARs) is a relevant platelet activation mechanism. Human (h) PAR1 antagonists are approved for antithrombotic therapy, but bleeding is a concerning complication. In addition to PARs, platelet glycoprotein (GP) Ibα also binds FIIa enhancing human platelet response to lower agonist concentrations ex vivo . Signaling through GPCRs is w...

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Literature Corpus work: be4df629-005b-5606-a5c2-35fa3b6b4b4a
DOI: 10.1101/2025.06.03.657740

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