Mice with reduced protease-activated receptor 4 reactivity show decreased venous thrombosis and platelet procoagulant activity.

doi:10.1016/j.jtha.2024.12.031

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Article

Mice with reduced protease-activated receptor 4 reactivity show decreased venous thrombosis and platelet procoagulant activity.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2025

Knauss Elizabeth A, Guci Johana, Luc Norman, Disharoon Dante, Huang Grace H, Gupta Anirban Sen, Nieman Marvin T

Abstract excerpt

BACKGROUND: Hypercoagulation and thrombin generation are major risk factors for venous thrombosis. Sustained thrombin signaling through protease-activated receptor (PAR) 4 promotes platelet activation, phosphatidylserine exposure, and subsequent thrombin generation. A single nucleotide polymorphism in PAR4 (rs2227376) changes proline to leucine extracellular loop 3, which decreases PAR4 reactivity and is...

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Identifiers

PMID: 39798922
DOI: 10.1016/j.jtha.2024.12.031
PMCID: PMC11992619

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