Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial.

doi:10.1016/j.bcmd.2018.07.004

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Article

Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial.

Blood cells, molecules & diseases - 1 Sept 2018

Tricoci Pierluigi, Neely Megan, Whitley Michael J, Edelstein Leonard C, Simon Lukas M, Shaw Chad, Fortina Paolo, Moliterno David J, Armstrong Paul W, Aylward Philip, White Harvey, Van de Werf Frans, Jennings Lisa K, Wallentin Lars, Held Claes, Harrington Robert A, Mahaffey Kenneth W, Bray Paul F

Abstract excerpt

Variation in platelet response to thrombin may affect the safety and efficacy of PAR antagonism. The Thr120 variant of the common single nucleotide polymorphism (SNP) rs773902 in the protease-activated receptor (PAR) 4 gene is associated with higher platelet aggregation compared to the Ala120 variant. We investigated the relationship between the rs773902 SNP with major bleeding and ischemic events, safety, and...

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Identifiers

PMID: 30055940
DOI: 10.1016/j.bcmd.2018.07.004
PMCID: PMC6097632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.