Article
Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects.
Thrombosis research - 1 Feb 2018
Morikawa Yoichiro, Kato Hisashi, Kashiwagi Hirokazu, Nishiura Nobuko, Akuta Keigo, Honda Shigenori, Kanakura Yuzuru, Tomiyama Yoshiaki
Abstract excerpt
BACKGROUND: Thrombin belongs to the most potent platelet agonists and activates human platelets through GPIbα and two protease activated receptors (PARs), PAR1 and PAR4. However, the details of thrombin receptor system, especially the role of PAR4 on human platelet activation is still not clear....
Topics
- Blood Platelets
- Calcium
- Enzyme Activation
- Extracellular Signal-Regulated MAP Kinases
- Humans
- Peptides
- Phosphorylation
- Platelet Activation
- Platelet Aggregation
- Platelet Glycoprotein GPIIb-IIIa Complex
- Polymorphism, Single Nucleotide
- Receptors, Thrombin