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Article

Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury.

American journal of hematology - 1 Feb 2012

Muehlschlegel Jochen D, Perry Tjörvi E, Liu Kuang-Yu, Fox Amanda A, Smith Shane A, Lichtner Peter, Collard Charles D, Shernan Stanton K, Hartwig John H, Body Simon C, Hoffmeister Karin M

Abstract excerpt

Protease-activated receptors (PAR)-1 and -4 are the principal receptors for thrombin-mediated platelet activation. Functional genetic variation has been described in the human PAR1 gene, but not in the PAR4 gene (F2RL3). We sought to identify variants in and around F2RL3 and to determine their association with perioperative myocardial injury (PMI) after coronary artery bypass graft surgery. We further explored...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22228373
DOI: 10.1002/ajh.22244
PMCID: PMC4371854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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