Article
Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.
Blood - 27 Nov 2014
Edelstein Leonard C, Simon Lukas M, Lindsay Cory R, Kong Xianguo, Teruel-Montoya Raúl, Tourdot Benjamin E, Chen Edward S, Ma Lin, Coughlin Shaun, Nieman Marvin, Holinstat Michael, Shaw Chad A, Bray Paul F
Abstract excerpt
Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. Recently, we reported 3.7-fold increased PAR4-mediated aggregation kinetics in platelets from black subjects compared with white subjects. We now show that platelets from blacks (n = 70) express 14% more PAR4 protein than those from whites (n = 84), but this difference is not associated with platelet PAR4 function....
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