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Article

Protease activated receptor-4: ready to be part of the antithrombosis spectrum.

Current opinion in hematology - 1 Sept 2024

Andrianova Izabella, Kowalczyk Mia, Denorme Frederik

Abstract excerpt

PURPOSE OF REVIEW: Cardiovascular disease is a major cause of death worldwide. Platelets play a key role in this pathological process. The serine protease thrombin is a critical regulator of platelet reactivity through protease activated receptors-1 (PAR1) and PAR4. Since targeting PAR4 comes with a low chance for bleeding, strategies blocking PAR4 function have great antithrombotic potential. Here, we reviewed...

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Identifiers

PMID: 38814792
DOI: 10.1097/MOH.0000000000000828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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