A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity.

doi:10.1016/j.jtha.2024.03.004

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Article

A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2024

Han Xu, Knauss Elizabeth A, Fuente Maria de la, Li Wei, Conlon Ronald A, LePage David F, Jiang Weihong, Renna Stephanie A, McKenzie Steven E, Nieman Marvin T

Abstract excerpt

BACKGROUND: Protease-activated receptor 4 (PAR4) mediates thrombin signaling on platelets and other cells. Our recent structural studies demonstrated that a single nucleotide polymorphism in extracellular loop 3 and PAR4-P310L (rs2227376) leads to a hyporeactive receptor. OBJECTIVES: The goal of this study was to determine how the hyporeactive PAR4 variant in extracellular loop 3 impacts platelet function in vivo...

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Identifiers

PMID: 38508397
DOI: 10.1016/j.jtha.2024.03.004
PMCID: PMC12036797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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