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Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes

14 Jul 2023

Abstract excerpt

Obesity-induced adipose tissue dysfunction can cause low-grade inflammation and downstream obesity comorbidities. Although preadipocytes may contribute to this pro-inflammatory environment, the underlying mechanisms are unclear. We used human primary preadipocytes from body mass index (BMI) -discordant monozygotic (MZ) twin pairs to generate epigenetic (ATAC-sequence) and transcriptomic (RNA-sequence) data for...

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PMID: 37452040
DOI: 10.1038/s41467-023-39919-y

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