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Article

Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci.

PLoS genetics - 1 Oct 2021

Perrin Hannah J, Currin Kevin W, Vadlamudi Swarooparani, Pandey Gautam K, Ng Kenneth K, Wabitsch Martin, Laakso Markku, Love Michael I, Mohlke Karen L

Abstract excerpt

Chromatin accessibility and gene expression in relevant cell contexts can guide identification of regulatory elements and mechanisms at genome-wide association study (GWAS) loci. To identify regulatory elements that display differential activity across adipocyte differentiation, we performed ATAC-seq and RNA-seq in a human cell model of preadipocytes and adipocytes at days 4 and 14 of differentiation. For...

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Adipocytes
Adipose Tissue
Allelic Imbalance
Chromatin Immunoprecipitation Sequencing
Epigenomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Techniques

Metabolic Diseases

Regulatory Sequences, Nucleic Acid

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Identifiers

PMID: 34699533
DOI: 10.1371/journal.pgen.1009865
PMCID: PMC8570510

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