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Article

Functional Annotation of GWAS Loci Using Public Transcriptome and Epigenome Datasets Reveals Non-Coding Genes and Regulatory Elements Which May Contribute to BMI.

International journal of molecular sciences - 4 Aug 2026

Yang Chunting, Yu Xiangyuan, Kleinbrink Erica L, King Dale, Chen Li, Lipovich Leonard

Abstract excerpt

Genome-wide association studies have identified numerous genetic variants statistically significantly associated with body mass index (BMI). However, the functional mechanisms underlying most associations between single nucleotide polymorphisms (SNPs) in non-coding regions and BMI remain poorly understood. Here, we implemented an integrative 7-criterion quantitative scoring system (gene localization, histone...

Topics

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Body Mass Index
Epigenome
GATA2 gene
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Regulatory Sequences, Nucleic Acid

RNA, Long Noncoding

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Open in PubMed Open full text

Identifiers

PMID: 42589667
DOI: 10.3390/ijms27157015
PMCID: PMC13466785

Genes

ETS2
GATA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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