Article
Genetic factors underlying discordance in chromatin accessibility between monozygotic twins.
Genome biology - 29 May 2014
Kim Kwoneel, Ban Hyo-Jeong, Seo Jungmin, Lee Kibaick, Yavartanoo Maryam, Kim Sang Cheol, Park Kiejung, Cho Seong Beom, Choi Jung Kyoon
Abstract excerpt
BACKGROUND: Open chromatin is implicated in regulatory processes; thus, variations in chromatin structure may contribute to variations in gene expression and other phenotypes. In this work, we perform targeted deep sequencing for open chromatin, and array-based genotyping across the genomes of 72 monozygotic twins to identify genetic factors regulating co-twin discordance in chromatin accessibility. RESULTS: We...
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