Article

Metabolic disease-relevant stimuli unmask context-dependent genetic regulation of cardiometabolic loci in human adipocytes

2026-08-17

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of loci associated with cardiometabolic disease, yet translating these associations into regulatory mechanisms, effector genes, and cellular programs remains a major challenge. A key limitation is that genetic effects are often highly context dependent, varying across cell states and environmental conditions that are difficult to model at scale. Here...

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Literature Corpus work: 0364162d-7e30-5ae6-aec1-b338d1357035
DOI: 10.64898/2026.08.12.744187

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