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Article

Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response.

The Journal of biological chemistry - 1 Jul 2023

Tan Ivan, Xu Shengli, Huo Jianxin, Huang Yuhan, Lim Hong-Hwa, Lam Kong-Peng

Abstract excerpt

The tumor suppressor Liver Kinase B1 (LKB1) is a multifunctional serine/threonine protein kinase that regulates cell metabolism, polarity, and growth and is associated with Peutz-Jeghers Syndrome and cancer predisposition. The LKB1 gene comprises 10 exons and 9 introns. Three spliced LKB1 variants have been documented, and they reside mainly in the cytoplasm, although two possess a nuclear-localization sequence...

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Source

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Identifiers

PMID: 37302555
DOI: 10.1016/j.jbc.2023.104906
PMCID: PMC10404683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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