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Article

LKB1 and cancer: The dual role of metabolic regulation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2020

Li Ting-Ting, Zhu Hai-Bin

Abstract excerpt

Liver kinase B1 (LKB1) is an essential serine/threonine kinase frequently associated with Peutz-Jeghers syndrome (PJS). In this review, we provide an overview of the role of LKB1 in conferring protection to cancer cells against metabolic stress and promoting cancer cell survival and invasion. This carcinogenic effect contradicts the previous conclusion that LKB1 is a tumor suppressor gene. Here we try to explain...

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Source

Identifiers

PMID: 33068936
DOI: 10.1016/j.biopha.2020.110872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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