Article
Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers.
Cancer letters - 1 Jul 2011
Herrmann Jennifer L, Byekova Yevgeniya, Elmets Craig A, Athar Mohammad
Abstract excerpt
LKB1 acts as a master kinase, with its major protein targets being the family of AMPKs. Through activation of multiple signaling pathways, LKB1's main physiologic functions involve regulating cellular growth, metabolism, and polarity. Germline mutations in LKB1 result in Peutz-Jeghers Syndrome, a rare cancer susceptibility syndrome. In addition, multiple LKB1 mutations have been identified in sporadic cancers,...
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