Article
The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression.
Cell research - 1 Jan 2010
Cao Yonghao, Li Hai, Liu Haifeng, Zheng Chao, Ji Hongbin, Liu Xiaolong
Abstract excerpt
LKB1 is a serine/threonine kinase that directly activates the energy sensor AMP-activated protein kinase (AMPK) in response to bioenergetic stress, and mainly acts as a tumor suppressor that controls cell polarity and proliferation. Although LKB1 is expressed in multiple tissues including the thymus and the spleen, its roles in T-cell development and function remain unknown. Here, we show that T-cell-specific...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.