Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The molecular mechanisms that underlie the tumor suppressor function of LKB1.

Acta biochimica et biophysica Sinica - 1 Feb 2009

Fan Dahua, Ma Chao, Zhang Haitao

Abstract excerpt

Germline mutations of the LKB1 tumor suppressor gene result in Peutz-Jeghers syndrome (PJS) characterized by intestinal hamartomas and increased incidence of epithelial cancers. Inactivating mutations in LKB1 have also been found in certain sporadic human cancers and with particularly high frequency in lung cancer. LKB1 has now been demonstrated to play a crucial role in pulmonary tumorigenesis, controlling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinase Kinases
Share to Apoptosis
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Genes, Tumor Suppressor

Share to Lung Neoplasms

Share to Peutz-Jeghers Syndrome

Share to Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 19204826
DOI: 10.1093/abbs/gmn011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The molecular mechanisms that underlie the tumor suppressor function of LKB1.PMID 19204826Read ↗

Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers.Semantic proximity Read ↗

LKB1, the multitasking tumour suppressor kinaseSemantic proximity Read ↗

Molecular mechanisms of tumor suppression by LKB1.Semantic proximity Read ↗

LKB1, a protein kinase regulating cell proliferation and polaritySemantic proximity Read ↗

Targeting the LKB1 tumor suppressor.Semantic proximity Read ↗

Controlling the master-upstream regulation of the tumor suppressor LKB1.Semantic proximity Read ↗

Insights into targeting LKB1 in tumorigenesisSemantic proximity Read ↗

The tumor suppressor kinase LKB1: lessons from mouse modelsSemantic proximity Read ↗

Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancer.Semantic proximity Read ↗

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progressionSemantic proximity Read ↗

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivatedSemantic proximity Read ↗

LKB1-dependent signaling pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.