Article
Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.
Nature communications - 19 Jan 2026
Schwartz Irene, Budroni Valentina, Meyenberg Mathilde, Hodakova Zuzana, Hornegger Harald, Hacker Kathrin, Schwartz Siegfried, Grabarczyk Daniel B, Ehrmann Julian F, Scinicariello Sara, Haselbach David, Menche Jörg, Clausen Tim, Karagöz G Elif, Versteeg Gijs A
Abstract excerpt
APOBEC family members play crucial roles in antiviral restriction. However, certain APOBEC3 (A3) proteins drive harmful hypermutation in humans, contributing to cancer. The cancer-associated A3 proteins are capable of transiting from the cytosol to the nucleus, where they can cause genome mutations. Here, we uncover a specific set of cellular pathways that protect genomic DNA from the major cancer-associated A3...
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