Article
The size and composition of haplotype reference panels impact the accuracy of imputation from low-pass sequencing in cattle.
Genetics, selection, evolution : GSE - 11 May 2023
Lloret-Villas Audald, Pausch Hubert, Leonard Alexander S
Abstract excerpt
BACKGROUND: Low-pass sequencing followed by sequence variant genotype imputation is an alternative to the routine microarray-based genotyping in cattle. However, the impact of haplotype reference panels and their interplay with the coverage of low-pass whole-genome sequencing data have not been sufficiently explored in typical livestock settings where only a small number of reference samples is available....
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