Article
Best practices for analyzing imputed genotypes from low-pass sequencing in dogs.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2022
Buckley Reuben M, Harris Alex C, Wang Guo-Dong, Whitaker D Thad, Zhang Ya-Ping, Ostrander Elaine A
Abstract excerpt
Although DNA array-based approaches for genome-wide association studies (GWAS) permit the collection of thousands of low-cost genotypes, it is often at the expense of resolution and completeness, as SNP chip technologies are ultimately limited by SNPs chosen during array development. An alternative low-cost approach is low-pass whole genome sequencing (WGS) followed by imputation. Rather than relying on high...
Topics
- Animals
- Case-Control Studies
- Dogs
- Genome-Wide Association Study
- Genotype
- Polymorphism, Single Nucleotide
- Whole Genome Sequencing