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Accurate imputation of African cattle genomes using a diverse reference panel.

BMC genomics - 6 May 2026

Ng'ang'a Said I, Ward James A, Rossiter Stephen J, Faulkes Chris G, Bougiouri Katia, McHugo Gillian P, Cotterill Fenton P D, Nyachieo Atunga, Thalmann Olaf, Medugorac Ivica, Krebs Stefan, Sonstegard Tad S, Hanotte Olivier, Bradley Daniel G, Vaughan-Smith Gary, MacHugh David E, Frantz Laurent A F

Abstract excerpt

BACKGROUND: In cattle, most commercial single-nucleotide polymorphism (SNP) genotyping arrays have been shown to be suboptimal for capturing genomic variation in non-European populations, particularly in African cattle. Low-coverage whole-genome sequencing (LCWGS) followed by imputation provides a cost-effective method for genotyping that is more adaptable and can outperform genotyping arrays. RESULTS: Here, we...

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Identifiers

PMID: 42092788
DOI: 10.1186/s12864-026-12818-4
PMCID: PMC13154541

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