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Article

A cautionary tale of low-pass sequencing and imputation with respect to haplotype accuracy.

Genetics, selection, evolution : GSE - 12 Jan 2024

Wragg David, Zhang Wengang, Peterson Sarah, Yerramilli Murthy, Mellanby Richard, Schoenebeck Jeffrey J, Clements Dylan N

Abstract excerpt

BACKGROUND: Low-pass whole-genome sequencing and imputation offer significant cost savings, enabling substantial increases in sample size and statistical power. This approach is particularly promising in livestock breeding, providing an affordable means of screening individuals for deleterious alleles or calculating genomic breeding values. Consequently, it may also be of value in companion animal genomics to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38216889
DOI: 10.1186/s12711-024-00875-w
PMCID: PMC10785484

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