Article
Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control.
Cell reports - 25 Apr 2023
Gao Yan, Khan Yousuf A, Mo Weike, White K Ian, Perkins Matthew, Pfuetzner Richard A, Trapani Josef G, Brunger Axel T, Nicolson Teresa
Abstract excerpt
The AAA+ NSF complex is responsible for SNARE complex disassembly both before and after membrane fusion. Loss of NSF function results in pronounced developmental and degenerative defects. In a genetic screen for sensory deficits in zebrafish, we identified a mutation in nsf, I209N, that impairs hearing and balance in a dosage-dependent manner without accompanying defects in motility, myelination, and innervation....
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