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Article

NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Dec 1998

Tolar L A, Pallanck L

Abstract excerpt

The SNARE hypothesis has been proposed to explain both constitutive and regulated vesicular transport in eukaryotic cells, including release of neurotransmitter at synapses. According to this model, a vesicle targeting/docking complex consisting primarily of vesicle- and target-membrane proteins, known as SNAREs, serves as a receptor for the cytosolic N-ethylmaleimide-sensitive fusion protein (NSF). NSF-dependent...

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Identifiers

PMID: 9852562
PMCID: PMC6793332

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NSF
SDS

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Related research

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NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.PMID 9852562Read ↗

Synaptic physiology and ultrastructure in comatose mutants define an in vivo role for NSF in neurotransmitter release.Semantic proximity Read ↗

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.Semantic proximity Read ↗

Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis.Semantic proximity Read ↗

Genetic interaction between shibire and comatose mutations in Drosophila suggest a role for snap-receptor complex assembly and disassembly for maintenance of synaptic vesicle cycling.Semantic proximity Read ↗

Activity-dependent interactions of NSF and SNAP at living synapses.Semantic proximity Read ↗

Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly.Semantic proximity Read ↗

Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses.Semantic proximity Read ↗

Genetic modifiers of comatose mutations in Drosophila: insights into neuronal NSF (N-ethylmaleimide-sensitive fusion factor) functions.Semantic proximity Read ↗

NSF is required for diverse endocytic modes by promoting fusion and fission pore closure in secretory cellsSemantic proximity Read ↗

Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophony.Semantic proximity Read ↗

The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF.Semantic proximity Read ↗

SNARE interactions in membrane trafficking: a perspective from mammalian central synapses.Semantic proximity Read ↗

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