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Article

Uncoupling the ATPase activity of the N-ethylmaleimide sensitive factor (NSF) from 20S complex disassembly.

Biochemistry - 15 Jan 2002

Matveeva Elena A, May Andrew P, He Ping, Whiteheart Sidney W

Abstract excerpt

The N-ethylmaleimide sensitive factor (NSF) plays a critical role in intracellular trafficking by disassembling soluble NSF attachment protein receptor (SNARE ) complexes. The NSF protomer consists of three domains (NSF-N, NSF-D1, and NSF-D2). Two domains (NSF-D1 and NSF-D2) contain a conserved approximately 230 amino acid cassette, which includes a distinctive motif termed the second region of homology (SRH)...

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Identifiers

PMID: 11781091
DOI: 10.1021/bi015632s

Genes

NSF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uncoupling the ATPase activity of the N-ethylmaleimide sensitive factor (NSF) from 20S complex disassembly.PMID 11781091Read ↗

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A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly.Semantic proximity Read ↗

The role of the N-D1 linker of the N-ethylmaleimide-sensitive factor in the SNARE disassembly.Semantic proximity Read ↗

Analysis of NSF mutants reveals residues involved in SNAP binding and ATPase stimulation.Semantic proximity Read ↗

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin.Semantic proximity Read ↗

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.Semantic proximity Read ↗

NSF is required for diverse endocytic modes by promoting fusion and fission pore closure in secretory cellsSemantic proximity Read ↗

Role of two nucleotide-binding regions in an N-ethylmaleimide-sensitive factor involved in vesicle-mediated protein transport.Semantic proximity Read ↗

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Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion.Semantic proximity Read ↗

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.Semantic proximity Read ↗

NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.Semantic proximity Read ↗

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