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Article

Dissecting the N-ethylmaleimide-sensitive factor: required elements of the N and D1 domains.

The Journal of biological chemistry - 1 Jan 2010

Zhao Chunxia, Matveeva Elena A, Ren Qiansheng, Whiteheart Sidney W

Abstract excerpt

N-Ethylmaleimide-sensitive factor (NSF) is a homo-hexameric member of the AAA(+) (ATPases associated with various cellular activities plus) family. It plays an essential role in most intracellular membrane trafficking through its binding to and disassembly of soluble NSF attachment protein (SNAP) receptor (SNARE) complexes. Each NSF protomer contains an N-terminal domain (NSF-N) and two AAA domains, a catalytic...

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Identifiers

PMID: 19887446
DOI: 10.1074/jbc.M109.056739
PMCID: PMC2804225

Genes

NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Dissecting the N-ethylmaleimide-sensitive factor: required elements of the N and D1 domains.PMID 19887446Read ↗

Uncoupling the ATPase activity of the N-ethylmaleimide sensitive factor (NSF) from 20S complex disassembly.Semantic proximity Read ↗

The role of the N-D1 linker of the N-ethylmaleimide-sensitive factor in the SNARE disassembly.Semantic proximity Read ↗

A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly.Semantic proximity Read ↗

Analysis of NSF mutants reveals residues involved in SNAP binding and ATPase stimulation.Semantic proximity Read ↗

NSF is required for diverse endocytic modes by promoting fusion and fission pore closure in secretory cellsSemantic proximity Read ↗

Role of two nucleotide-binding regions in an N-ethylmaleimide-sensitive factor involved in vesicle-mediated protein transport.Semantic proximity Read ↗

Engineered interfaces of an AAA+ ATPase reveal a new nucleotide-dependent coordination mechanism.Semantic proximity Read ↗

Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control.Semantic proximity Read ↗

Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion.Semantic proximity Read ↗

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.Semantic proximity Read ↗

NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.Semantic proximity Read ↗

High affinity associations with α-SNAP enable calcium entry via Orai1 channels.Semantic proximity Read ↗

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