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Article

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.

Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2001

Littleton J T, Barnard R J, Titus S A, Slind J, Chapman E R, Ganetzky B

Abstract excerpt

Soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE)-mediated fusion of synaptic vesicles with the presynaptic-plasma membrane is essential for communication between neurons. Disassembly of the SNARE complex requires the ATPase N-ethylmaleimide-sensitive fusion protein (NSF). To determine where in the synaptic-vesicle cycle NSF functions, we have undertaken a genetic analysis of comatose...

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Identifiers

PMID: 11593041
DOI: 10.1073/pnas.221450198
PMCID: PMC59797

Genes

NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.PMID 11593041Read ↗

NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.Semantic proximity Read ↗

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Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly.Semantic proximity Read ↗

Synaptic physiology and ultrastructure in comatose mutants define an in vivo role for NSF in neurotransmitter release.Semantic proximity Read ↗

Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis.Semantic proximity Read ↗

Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses.Semantic proximity Read ↗

Activity-dependent interactions of NSF and SNAP at living synapses.Semantic proximity Read ↗

Genetic modifiers of comatose mutations in Drosophila: insights into neuronal NSF (N-ethylmaleimide-sensitive fusion factor) functions.Semantic proximity Read ↗

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Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion.Semantic proximity Read ↗

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