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Article

Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses.

Journal of neurobiology - 15 Jun 2002

Stewart Bryan A, Mohtashami Mahmood, Rivlin Patricia, Deitcher David L, Trimble William S, Boulianne Gabrielle L

Abstract excerpt

N-ethylmaleimide sensitive fusion protein (NSF) is an ATPase necessary for vesicle trafficking, including exocytosis. Current models hold that NSF is required in a step that readies vesicles for fusion by disassembling postfusion SNARE protein complexes allowing them to participate in further rounds of vesicle cycling. Whereas most organisms have only one NSF isoform, Drosophila has two. dNSF1 is the predominant...

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Source

Identifiers

PMID: 12150502
DOI: 10.1002/neu.10059

Genes

NSF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses.PMID 12150502Read ↗

Disruption of synaptic development and ultrastructure by Drosophila NSF2 alleles.Semantic proximity Read ↗

Synaptic vesicle mobility and presynaptic F-actin are disrupted in a N-ethylmaleimide-sensitive factor allele of Drosophila.Semantic proximity Read ↗

Synaptic physiology and ultrastructure in comatose mutants define an in vivo role for NSF in neurotransmitter release.Semantic proximity Read ↗

Lethal comatose mutation in Drosophila reveals possible role for NSF in neurogenesis.Semantic proximity Read ↗

Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis.Semantic proximity Read ↗

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.Semantic proximity Read ↗

A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth.Semantic proximity Read ↗

Genetic modifiers of comatose mutations in Drosophila: insights into neuronal NSF (N-ethylmaleimide-sensitive fusion factor) functions.Semantic proximity Read ↗

Genetic analysis of soluble N-ethylmaleimide-sensitive factor attachment protein function in Drosophila reveals positive and negative secretory roles.Semantic proximity Read ↗

NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.Semantic proximity Read ↗

Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants.Semantic proximity Read ↗

The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF.Semantic proximity Read ↗

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