Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of NSF mutants reveals residues involved in SNAP binding and ATPase stimulation.

Biochemistry - 23 Apr 2002

Horsnell William G C, Steel Gregor J, Morgan Alan

Abstract excerpt

N-Ethylmaleimide-sensitive fusion protein (NSF) and its yeast orthologue, Sec18, are cytoplasmic AAA(+) ATPases required for most intracellular membrane fusion events. The primary function of NSF is thought to be the disassembly of cis-SNARE complexes, thus allowing trans-SNARE complex formation and subsequent membrane fusion. The importance of NSF/Sec18 in intracellular membrane traffic in vivo is highlighted by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Aspartic Acid
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethylmaleimide

Share to Glycine

Share to Membrane Fusion

Share to SNARE Proteins

Share to Vesicular Transport Proteins

Source

Identifiers

PMID: 11955072
DOI: 10.1021/bi0160359

Genes

NSF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of NSF mutants reveals residues involved in SNAP binding and ATPase stimulation.PMID 11955072Read ↗

Uncoupling the ATPase activity of the N-ethylmaleimide sensitive factor (NSF) from 20S complex disassembly.Semantic proximity Read ↗

Dissecting the N-ethylmaleimide-sensitive factor: required elements of the N and D1 domains.Semantic proximity Read ↗

Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion.Semantic proximity Read ↗

Genetic analysis of soluble N-ethylmaleimide-sensitive factor attachment protein function in Drosophila reveals positive and negative secretory roles.Semantic proximity Read ↗

UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans.Semantic proximity Read ↗

The role of the N-D1 linker of the N-ethylmaleimide-sensitive factor in the SNARE disassembly.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.Semantic proximity Read ↗

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.Semantic proximity Read ↗

Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control.Semantic proximity Read ↗

Selective activation of cognate SNAREpins by Sec1/Munc18 proteins.Semantic proximity Read ↗

Lethal comatose mutation in Drosophila reveals possible role for NSF in neurogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.