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Uncovering genetic diversity and admixture of British Africans with HLA alleles inferred from whole genome sequencing.

European journal of human genetics : EJHG - 1 Aug 2025

Liu Yunjia, Meng Ze, Adrianto Indra, Levin Albert M, Mi Qing-Sheng, Wang Qiang, Gui Hongsheng

Abstract excerpt

The human leukocyte antigen (HLA) region is highly diverse and plays a crucial role in immune regulation and antigen presentation. Accurate HLA typing is essential for understanding disease susceptibility, transplantation compatibility, and pharmacogenetics. However, its application in African descent populations is challenging due to complex linkage disequilibrium patterns and the lack of ancestry-matched...

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PMID: 40670583
DOI: 10.1038/s41431-025-01888-9
PMCID: PMC12322232

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