Article
HLA-G genetic diversity and evolutive aspects in worldwide populations.
Scientific reports - 29 Nov 2021
Castelli Erick C, de Almeida Bibiana S, Muniz Yara C N, Silva Nayane S B, Passos Marília R S, Souza Andreia S, Page Abigail E, Dyble Mark, Smith Daniel, Aguileta Gabriela, Bertranpetit Jaume, Migliano Andrea B, Duarte Yeda A O, Scliar Marília O, Wang Jaqueline, Passos-Bueno Maria Rita, Naslavsky Michel S, Zatz Mayana, Mendes-Junior Celso Teixeira, Donadi Eduardo A
Abstract excerpt
HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents substantial nucleotide variability in its regulatory regions. However, it encodes a limited number of proteins compared to classical HLA class I genes. We characterized the HLA-G genetic variability in 4640 individuals from 88 different population samples across the globe by using a state-of-the-art method to characterize polymorphisms and...
Topics
- 3' Untranslated Regions
- Alleles
- Computational Biology
- Dimerization
- Evolution, Molecular
- Gene Frequency
- Genes, MHC Class I
- Genetic Variation
- Genetics, Population