Article
Widespread non-coding polymorphism in HLA class II genes of International HLA and Immunogenetics Workshop cell lines.
HLA - 1 Apr 2022
Turner Thomas R, Hayward Daniel R, Gymer Arthur W, Barker Dominic J, Leen Gayle, Cambridge Charlotte A, Macpherson Hannah L, Georgiou Xenia, Cooper Michael A, Lucas Jonathan A M, Nadeem Daud, Robinson James, Mayor Neema P, Marsh Steven G E
Abstract excerpt
As the primary genetic determinant of immune recognition of self and non-self, the hyperpolymorphic HLA genes play key roles in disease association and transplantation. The large, variably sized HLA class II genes have historically been less well characterized than the shorter HLA class I genes....
Topics
- Alleles
- Cell Line
- Gene Frequency
- Genes, MHC Class II
- Haplotypes
- Humans
- Immunogenetics