Article

Single-Platform Nanopore Sequencing Enables Diploid Telomere-to-Telomere Genome Assembly and Haplotype-Resolved 3D Chromatin Maps

2026-03-21

Abstract excerpt

Telomere-to-telomere (T2T) genome assembly has transformed human genomics by resolving centromeres, segmental duplications, and other previously inaccessible regions. However, most diploid T2T assemblies rely on the combination of multi-platform sequencing strategies including short read genome sequencing, PacBio HiFi, Oxford Nanopore ultra-long reads, and chromatin conformation capture data (Hi-C), limiting both...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d2ca9cc-9a71-573b-90d1-eb8e9525ddb3
DOI: 10.64898/2026.03.19.712851

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Platform Nanopore Sequencing Enables Diploid Telomere-to-Telomere Genome Assembly and Haplotype-Resolved 3D Chromatin MapsDOI 10.64898/2026.03.19.712851Read

Gapless assembly of complete human and plant chromosomes using only nanopore sequencingSemantic proximity Read

Efficient and accurate near telomere-to-telomere haplotype reconstruction of diploid genomesSemantic proximity Read

The Revised Diploid Genome Sequence of an Individual Human: An Optimized Assembly Workflow for Scaling of near Telomere-to-Telomere AssembliesSemantic proximity Read

Telomere-to-telomere assembly of a complete human X chromosomeSemantic proximity Read

Nanopore whole-genome sequencing reveals conserved chromosome-specific telomere architecture across tissues and populationsSemantic proximity Read

Telomere-to-Telomere Phased Genome Assembly Using HERRO-Corrected Simplex Nanopore ReadsSemantic proximity Read

Verkko: telomere-to-telomere assembly of diploid chromosomesSemantic proximity Read

Single-molecule architecture and heterogeneity of human telomeric DNA and chromatinSemantic proximity Read

NPGREAT: Assembly of the human subtelomere regions with the use of ultralong Nanopore reads and Linked-ReadsSemantic proximity Read

A Complete Telomere-to-Telomere Diploid Reference Genome for Indian PopulationSemantic proximity Read

A Telomere-to-Telomere Diploid Reference Genome and Centromere Structure of the Chinese QuartetSemantic proximity Read

Epigenetic Patterns in a Complete Human GenomeSemantic proximity Read