Article

Haplotype-resolved genome architecture mapping uncovers pervasive structural heterogeneity between human homologous chromosomes

2026-06-18

Abstract excerpt

Resolving the three-dimensional structure of chromatin with haplotype specificity remains a fundamental challenge for understanding genetic and epigenetic contributions to gene regulation in healthy development and in disease. Phasing of chromatin contacts derived by ligation-dependent methods relies on high single-nucleotide variant (SNV) density, which limits its applicability in human genomes where SNVs are spa...

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Literature Corpus work: 790c400d-2bf9-5ed7-b74f-3bc7dc91eb7e
DOI: 10.64898/2026.06.16.732681

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