Article

Efficient and accurate near telomere-to-telomere haplotype reconstruction of diploid genomes

2026-06-16

Abstract excerpt

<title>Abstract</title> <p>Telomere-to-telomere (T2T) haplotype-resolved assembly represents the gold standard for capturing full diploid genetic diversity, enabling precise dissection of allele-specific expression, compound heterozygous disease mutations, and species evolutionary histories. However, recent landmark single-platform Oxford Nanopore (ONT) simplex read assemblers produce near-T2T assemblies plagued...

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Literature Corpus work: 81d8d164-114f-5a09-9412-12fe3c1284b3
DOI: 10.21203/rs.3.rs-9894166/v1

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