Article
Transcription-wide impact by RESCUE-induced off-target single-nucleotide variants in mammalian cells.
Journal of molecular cell biology - 13 Jun 2023
Li Guo, Zhu Xiaoning, Wang Yihan, Ma Hongru, Wang Yuzhe, Wu Hanyu, Li Xiangyang, Wang Yiling, Gao Jianen, Chen Xuexin, Huang Xingxu, Yao Yuan, Hu Xiaoxiang
Abstract excerpt
RNA base editing is a promising tool in precise molecular therapy. Currently, there are two widely used RNA base editors, REPAIR and RESCUE. REPAIR only facilitates A-to-I conversions, while RESCUE performs both A-to-I and C-to-U conversions. Thus, RESCUE can generate twice the number of mutations compared to REPAIR. However, transcription-wide impact due to RESCUE-induced off-target single-nucleotide variants...
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