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Article

ecRESCUE: a novel ecDHFR-regulated RESCUE system with reduced RNA off-targeting activity.

Cell communication and signaling : CCS - 31 Jul 2021

Wang Yihan, Li Guo, Li Xiangyang, Wang Yuzhe, Huang Xingxu, Hu Xiaoxiang, Gao Jianen

Abstract excerpt

The currently available RESCUE RNA base editing system demonstrates considerable potential for the treatment of genetic diseases at the transcriptional level. However, the relatively high incidence of off-target events hampers the precise RNA editing, thereby limiting its use in the clinical setting. This study describes a new RNA base editing method, named ecRESCUE, which utilizes inducible stabilization of the...

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Identifiers

PMID: 34332602
DOI: 10.1186/s12964-021-00759-2
PMCID: PMC8325194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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