Article

ecRESCUE: a novel ecDHFR-regulated RESCUE system with reduced RNA off-targeting activity

2021-04-30

Abstract excerpt

<title>Abstract</title> <p>The currently available RESCUE RNA base editing system demonstrates considerable potential for the treatment of genetic diseases at the transcriptional level. However, the relatively high incidence of off-target events hampers the precise RNA editing, thereby limiting its use in the clinical setting. This study describes a new RNA base editing method, named ecRESCUE, which utilizes indu...

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Literature Corpus work: 24ff4c14-46d9-5d92-b3ab-6205a6e29fe3
DOI: 10.21203/rs.3.rs-459640/v1

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