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Article

An ADAR2-mimic base editor for efficient C-to-U RNA editing in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2025

Hao Chenhui, Zhang Niubing, Mo Ouyang, Chen Ping, Liu Qian, Cheng Xiang, Li Xuan, Hao Pei

Abstract excerpt

RNA base editing has the capability to rewrite genetic codes while offering improved safety due to its reversibility and temporal-spatial tunability. The development of cytosine-to-uridine editors faces issues of DNA mutagenic activity of APOBECs and the large-size anchoring domains associated with immunogenicity due to their microbial origin. To address these issues, we took an approach by returning to the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41196347
DOI: 10.1073/pnas.2505269122
PMCID: PMC12625888

Genes

ADAR

Variants

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