Article

Small nuclear RNAs enhance protein-free RNA-programmable base conversion on mammalian coding transcripts

2024-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Endogenous U small nuclear RNAs (U snRNAs) form RNA-protein complexes responsible for eukaryotic processing of pre-mRNA into mature mRNA. Previous studies have demonstrated the utility of guide-programmable U snRNAs in targeted exon inclusion and exclusion. We investigated whether snRNAs can also enhance conversion of RNA bases over state-of-the-art RNA targeting technologies in human cells. Whe...

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Literature Corpus work: 03a521f8-8c76-572c-9dd3-df654501e5a8
DOI: 10.1101/2024.06.12.598766

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